Publications

Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice.

Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice.

Intra-muscular mRNA vaccines are poor inducers of mucosal immunity

Intestinal Candida albicans overgrowth in IgA deficiency

Mycobiota control : the IgA connection.

The claudin-like apicomplexan microneme protein is required for gliding motility and infectivity of Plasmodium sporozoites

O. Silvie’s team has identified a Plasmodium protein that is essential for the motility and infectivity of sporozoites, the mosquito-transmitted forms of the malaria-causing parasite. This protein, called CLAMP, could constitute a new vaccine target.

Plasmodium sporozoites require the protein B9 to invade hepatocytes

O. Silvie’s team has identified a Plasmodium protein that is essential for the infection of hepatocytes during malaria. This protein, called B9, could constitute a new vaccine target.

T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens

A novel CIMI collaboration underlines the key role played by the immune/microbiota interface in the pre-education of the human antibody repertoire.

“Lower disease activity but higher risk of severe COVID- 19 and herpes zoster in patients with systemic lupus erythematosus with pre-existing autoantibodies neutralising IFN-α”

Trans-cellular tunnels induced by the fungal pathogen Candida albicans facilitate invasion through successive epithelial cells without host damage

Trans-cellular tunnels induced by the fungal pathogen Candida albicans facilitate invasion through successive epithelial cells without host damage.

A personalized precision medicine approach is needed to treat Covid-19 as more than one type of “Cytokine storm” is induced by SARS-CoV-2

The severe form of Covid-19 is known to be associated with the excessive elevation of many cytokines, a condition termed “cytokine storm”. Therapy with biological agents intended to block these cytokines, for example anti-interleukin-6 or anti-interleukin-1 antibodies, was already tried, albeit with a limited success.

Particularly active antibodies as a barrier to SARS-CoV-2

Teams from the Pitié-Salpêtrière AP-HP hospital, Sorbonne University, Inserm and the Pasteur Institute have carried out work to study the role played by IgA-type antibodies in protecting the body against Covid-19 in the mucous membranes, particularly the respiratory tract.