![](https://cimiparis.fr/wp-content/uploads/2024/04/img-CP-vaccin-1-848x565-2.jpg)
Intra-muscular mRNA vaccines are poor inducers of mucosal immunity
![](https://cimiparis.fr/wp-content/uploads/2023/06/20230601_11232614-1.png)
Intestinal Candida albicans overgrowth in IgA deficiency
Mycobiota control : the IgA connection.
![](https://cimiparis.fr/wp-content/uploads/2023/04/CLAMP-image-1.jpg)
The claudin-like apicomplexan microneme protein is required for gliding motility and infectivity of Plasmodium sporozoites
O. Silvie’s team has identified a Plasmodium protein that is essential for the motility and infectivity of sporozoites, the mosquito-transmitted forms of the malaria-causing parasite. This protein, called CLAMP, could constitute a new vaccine target.
![](https://cimiparis.fr/wp-content/uploads/2023/02/B9-image-1-e1675334219584.jpg)
Plasmodium sporozoites require the protein B9 to invade hepatocytes
O. Silvie’s team has identified a Plasmodium protein that is essential for the infection of hepatocytes during malaria. This protein, called B9, could constitute a new vaccine target.
![](https://cimiparis.fr/wp-content/uploads/2023/02/Eq-GG-1-scaled-e1675334161978.jpg)
T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens
A novel CIMI collaboration underlines the key role played by the immune/microbiota interface in the pre-education of the human antibody repertoire.
![](https://cimiparis.fr/wp-content/uploads/2023/01/FRM-1.png)
Team’s FRM 2022 – G Gorochov
Guy Gorochov’s team has been awarded the Equipe FRM 2022 label for the project «Study and manipulation of host-microbiota mutualism regulated by immunoglobulin A»
“Exploring the microbiome to displace multi-drug resistant Enterobacteria from the gut”
« Identification of key components of proteostasis regulation for diagnosis and targeting of inflammatory diseases and cancer »
“Lower disease activity but higher risk of severe COVID- 19 and herpes zoster in patients with systemic lupus erythematosus with pre-existing autoantibodies neutralising IFN-α”
Trans-cellular tunnels induced by the fungal pathogen Candida albicans facilitate invasion through successive epithelial cells without host damage
Trans-cellular tunnels induced by the fungal pathogen Candida albicans facilitate invasion through successive epithelial cells without host damage.