Team Leader :
Boissonnas AlexandreContact the team
Our team focus on the origin and function of myeloid cells in infectious diseases and cancer. We try to decipher the regulation of pro and anti-inflammatory activities mediated by these innate immune cells upon insult and understand how the balance tips toward dysfunctional response and worsen the pathology. Our team has developed expertise in multiparametric immuno-monitoring of myeloid cells in patients and mouse preclinical models including flow, mass cytometry and transcriptomic analyses as well as cutting-edge non-linear optical imaging processes to monitor the dynamic of myeloid cells in vivo.
The team members
Our research focus on 3 axes
- Myeloid cells
- Live imaging
1. Dynamic of the myeloid cells
Myeloid cells exert very intense trafficking between the blood vasculature and the tissue with a high turnover. We develop in vivo studies to monitor the kinetic of their mobilization across different tissues and track their behavior by live imaging in animal models.
2. Innate immune dysfunction
Innate immune dysfunction represents a major axis in in the pathophysiology of numerous inflammatory diseases such as sepsis, COVID and cancers.
Immunomonitoring the innate immune cells in animal models and human samples through “omic” approaches like mass cytometry, RNA sequencing and multiplex imaging is central in our activity to decipher phenotypic and functional alterations and uncover biomarkers for therapeutic purposes.
3. Origin and function of phagocytes in inflammation
The field of the mononuclear phagocyte system has significantly evolved this past decade. The concept of phagocyte origin has raised new important questions on the respective contribution of resident and inflammatory macrophages in response to infection, cancer development and tissue injury.
- Technical developments Mass and spectral cytometry, live imaging
- Bench to Bedside (in vivo models and clinical samples)
- Team work
- National and international interactions and collaborations