of Immunology
and Microbial 

The Centre for Immunology and Microbial Infections (Cimi) is a mixed research unit created in 2014. It is affiliated to Sorbonne University, Inserm and CNRS. The Cimi is located on the campus of Sorbonne University’s Faculty of Medicine at the Pitié-Salpêtrière site in Paris.

The location encourages a strong dynamic and interactions between the research teams and the hospital services. Approximately 150 people work at the Cimi, including researchers, teachers, technical personnel and research support staff.

The research conducted at the Cimi explores  how the immune system functions and host-pathogen interactions, but also aims to develop immune-based therapeutic strategies and new ways to fight infectious diseases.

Topics: immunology, inflammation, immuno-oncology, microbiology, host-pathogen interactions, antibiotic resistance, vaccinology.

A word from the director of Cimi-Paris

Since its creation in January 2014, the Cimi has been developing research programmes dedicated to the development of knowledge in immunology and microbiology with the aim of preventing and curing infections, but also slowing and mitigating inflammatory processes.

Researchers are concerned with everything from molecules essential for immune function to whole organisms (microbes, mice and humans), from physiology to pathology, from disease models to the design of new therapeutic approaches.

Due to, among other things, its location within the Pitié-Salpêtrière University Hospital, the Cimi maintains a unique environment that allows clinicians and scientists to collaborate and think together on human infectious diseases.

Biology and medicine are integrated to foster strong and productive interactions between basic and clinical research, facilitating the emergence of new concepts for therapeutic applications.

The 150 or so members of the Cimi pool their expertise in virology, bacteriology, parasitology, immunology and clinical research, with the aim of developing innovative, cutting-edge research in these fields.

Quality, originality and innovation of our research are thus guaranteed.

In this context, the Cimi has been able to react to major epidemic crises, particularly in the face of Zika, HIV, Ebola, Malaria and recently COVID-19.

The centre’s teams have been responsive and strong in federative proposals.

They have thus collaborated to study different facets of the pandemic virus and actively participate in the discoveries that allow us to better understand and combat the SARS-CoV-2.

The Cimi is therefore at the centre of the fight against infectious diseases, while maintaining strong values for the dissemination of knowledge and its applications, to the hospital environment and research, as well as for the training of future researchers, hospital researchers and practitioners.

Recent news

The effectiveness of a vaccine against #HIV

29 October 2021

Dr Behazine Combadière, a lead investigator at the Centre for Immunology and Infectious Diseases @INSERM is working on predicting the effectiveness of a vaccine against #HIV which is concurrently advancing the #CovidVaccine development research.

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Vaccine responses against SARS-CoV-2 variants examined in people with lupus

08 October 2021

The majority of people with systemic lupus erythematosus (SLE) who respond to messenger (m)RNA COVID-19 vaccines also generate an antibody response against emerging SARS-CoV-2 variants, albeit with reduced neutralizing activity against variants bearing the E484K mutation, researchers report.

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A personalized precision medicine approach is needed to treat Covid-19 as more than one type of “Cytokine storm” is induced by SARS-CoV-2

07 October 2021

The severe form of Covid-19 is known to be associated with the excessive elevation of many cytokines, a condition termed “cytokine storm”. Therapy with biological agents intended to block these cytokines, for example anti-interleukin-6 or anti-interleukin-1 antibodies, was already tried, albeit with a limited success.

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