The Centre for Immunology and Microbial Infections (Cimi) is a mixed research unit created in 2014. It is affiliated to Sorbonne University, Inserm and CNRS. The Cimi is located on the campus of Sorbonne University’s Faculty of Medicine at the Pitié-Salpêtrière site in Paris.
The location encourages a strong dynamic and interactions between the research teams and the hospital services. Approximately 150 people work at the Cimi, including researchers, teachers, technical personnel and research support staff.
The research conducted at the Cimi explores how the immune system functions and host-pathogen interactions, but also aims to develop immune-based therapeutic strategies and new ways to fight infectious diseases.
Topics: immunology, inflammation, immuno-oncology, microbiology, host-pathogen interactions, antibiotic resistance, vaccinology.
The claudin-like apicomplexan microneme protein is required for gliding motility and infectivity of Plasmodium sporozoites
O. Silvie’s team has identified a Plasmodium protein that is essential for the motility and infectivity of sporozoites, the mosquito-transmitted forms of the malaria-causing parasite. This protein, called CLAMP, could constitute a new vaccine target.
Plasmodium sporozoites require the protein B9 to invade hepatocytes
O. Silvie’s team has identified a Plasmodium protein that is essential for the infection of hepatocytes during malaria. This protein, called B9, could constitute a new vaccine target.
T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens
A novel CIMI collaboration underlines the key role played by the immune/microbiota interface in the pre-education of the human antibody repertoire.
Team’s FRM 2022 – G Gorochov
Guy Gorochov’s team has been awarded the Equipe FRM 2022 label for the project «Study and manipulation of host-microbiota mutualism regulated by immunoglobulin A»