“Lower disease activity but higher risk of severe COVID- 19 and herpes zoster in patients with systemic lupus erythematosus with pre-existing autoantibodies neutralising IFN-α” 17 August 2022

Publication – O Silvie

O. Silvie’s team has identified a Plasmodium protein that is essential for the infection of hepatocytes during malaria. This protein, called B9, could constitute a new vaccine target.

Publication – D Scalbert Sterlin

Delphine SCALBERT STERLIN from team CIMI nb 6 contributed to a program lead by Sandra WELLER from the WEILL/REYNAUD lab (Université Paris Cité, INSERM U1151, CNRS UMR-8253, Institut Necker Enfants Malades INEM) to generate novel bacterial flow cytometry data supporting a model in which conventional vaccine responses, in this case Pneumovax T-independent B cell responses, most likely originate from prediversified mucosal immune responses against bacterial antigens that subsequently acquired pneumococcal cross-reactivity through somatic hypermutation

Team’s FRM 2022 – G Gorochov

Microbiota and the immune system form a symbiosis. One cannot function optimally without the other. Antibody immune deficiency is a frequent disease for which there is no replacement therapy to compensate for the lack of antibodies in the intestine. Yet, these antibodies are important in regulating our microbiota. We will further characterize the abnormalities of the microbiota in antibody deficiency. We will focus not only on bacteria but also on other microbes such as viruses and fungi that inhabit our intestines and that are associated with a deterioration in the state of health of patients, due often to fatal hepatic complications. At the same time, using an original model of humanized mice reproducing the secretory antibody deficiency, we will test new supplementation of oral drug antibodies aimed at restoring microbiota balance. Such preparations would also find applications in all situations of imbalance between microbiota and immunity.

“Exploring the microbiome to displace multi-drug resistant Enterobacteria from the gut”

« Identification of key components of proteostasis regulation for diagnosis and targeting of inflammatory diseases and cancer »

“Lower disease activity but higher risk of severe COVID- 19 and herpes zoster in patients with systemic lupus erythematosus with pre-existing autoantibodies neutralising IFN-α”